[PDF] Ligand Design for G Protein-coupled Receptors (Methods and Principles in Medicinal Chemistry) Didier Rognan, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

Content: G protein-coupled receptors in the human genome / Robert Fredriksson and Helgi B. Schio?th — Why G protein-coupled receptors databases are needed / Jacques Haiech … [et al.] — A novel drug screening assay for G protein-coupled receptors / Brian F. O’Dowd … [et al.] — Importance of GPCR dimerization for function : the case of the class C GPCRs / Laurent Pre?zeau … [et al.] — Molecular mechanisms of GPCR activation / Robert P. Bywater and Paul Denny-Gouldson — Allosteric properties and regulation of G protein-coupled receptors / Jean-Luc Galzi … [et al.] — Chemogenomics approaches to ligand design / Thomas Klabunde — Strategies for the design of pGPCR-targeted libraries / Nikolay P. Savchuk, Sergey E. Tkachenko, and Konstantin V. Balakin — Ligand-based rational design : virtual screening / David E. Clark and Christopher Higgs — 3-D structure of G protein-coupled receptors / Leonardo Pardo … [et al.] — 7TM models in structure-based drug design / Frank E. Blaney, Anna-Maria Capelli, and Giovanna Tedesco — Receptor-based rational design : virtual screening / Didier Rognan