{PDF} The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition

The most encyclopedic book on the pancreas – providing clear guidance for practicing clinicians & surgeons

In the past decade, extraordinary developments in diagnostic and therapeutic radiology and endoscopy have been coupled with major advances in surgical techniques and basic sciences. As a result the management of pancreatic disorders is now handled by a multidisciplinary team.

This book shows you how to achieve superior patient management by taking the team approach to in-hospital care.

For all known pancreatic disorders, it details the latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology.

The Editor and author team are leading pancreatologists of high international repute and they present global best-practice using the newest diagnosis and treatment principles.

A timely section on early and late outcome data considers the benefits of management including chemotherapy and immune therapy. Carefully incorporating the latest evidence based data, the book also discusses early diagnosis, limited surgical treatment, oncology, treatment results and the option of transplantation.

This new edition contains more than 400 illustrations, line drawings and radiographs to provide a step-by-step approach to endoscopic techniques and surgical procedures. With The Pancreas, Second Edition, you can achieve a greater understanding of the principles of surgical treatment in one reference point.Content:
Chapter 1 Definitions of Pancreatic Diseases and their Complications (pages 1?6): David C. Whitcomb and Hans G. Beger
Chapter 2 The History of the Pancreas (pages 7?41): Irvin M. Modlin, Manish C. Champaneria, Anthony K. C. Chan, Mark Kidd and Geeta N. Eick
Chapter 3 Development of the Pancreas and Related Structures (pages 42?49): Brian Lewis
Chapter 4 Anatomy and Fine Structure (pages 50?57): Dale E. Bockman
Chapter 5 Congenital and Inherited Anomalies (pages 58?68): Martin Zenker and Markus M. Lerch
Chapter 6 Physiology of Acinar Cell Secretion (pages 69?77): Ole H. Petersen
Chapter 7 Physiology of Duct Cell Secretion (pages 78?90): Min Goo Lee and Shmuel Muallem
Chapter 8 Physiology of Experimental Pancreatitis (pages 91?106): Ashok K. Saluja, Vijay P. Singh and Phoebe Phillips
Chapter 9 Physiology of Sphincter of Oddi Function (pages 107?112): James Toouli
Chapter 10 Neurohormonal and Hormonal Control of Exocrine Pancreatic Secretion (pages 113?126): Chung Owyang
Chapter 11 Regulation of Pancreatic Protein Synthesis and Growth (pages 127?135): Maria Dolors Sans, Stephen J. Crozier and John A. Williams
Chapter 12 Insulo?Acinar Relationship (pages 136?142): Keiko Shiratori and Kyoko Shimizu
Chapter 13 Etiopathogenesis and Epidemiology of Alcohol?Induced Acute Pancreatitis (pages 143?153): Minoti V. Apte, Ron C. Pirola and Jeremy S. Wilson
Chapter 14 Etiology and Epidemiology of Biliary Acute Pancreatitis (pages 154?162): Michael G. T. Raraty and John P. Neoptolemos
Chapter 15 Acute Pancreatitis Associated with Congenital Anomalies (pages 163?171): Tracy C. Grikscheit and Andrew L. Warshaw
Chapter 16 Acute Pancreatitis Associated with Metabolic, Infectious, and Drug?Related Diseases (pages 172?183): Stefan Turi, Matthias Kraft and Markus M. Lerch
Chapter 17 Acute Pancreatitis in Children (pages 184?192): Mark E. Lowe and Veronique D. Morinville
Chapter 18 Understanding of Acute Pancreatitis from Animal Experiments (pages 193?199): Thomas Foitzik
Chapter 19 Genetic Factors in Acute Pancreatitis (pages 200?208): David C. Whitcomb and Georgios I. Papachristou
Chapter 20 Histopathology of Acute Pancreatitis (pages 209?213): Gunter Kloppel
Chapter 21 Molecular, Biochemical, and Metabolic Abnormalities of Acute Pancreatitis (pages 214?225): Julia Mayerle, F. Ulrich Weiss, Walter Halangk and Markus M. Lerch
Chapter 22 Clinical Course of Alcoholic Acute Pancreatitis (pages 226?230): Roland H. Pfutzer and Manfred V. Singer
Chapter 23 Clinical Course and Treatment Principles of Biliary Acute Pancreatitis (pages 231?241): Julia Mayerle, Ashok K. Saluja and Markus M. Lerch
Chapter 24 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis (pages 242?254): Bettina M. Rau
Chapter 25 Imaging Acute Edematous?Interstitial and Necrotizing Pancreatitis (pages 255?272): Patrick C. Freeny
Chapter 26 Treatment of Acute Pancreatitis (pages 273?287): Paul Georg Lankisch, Mark Topazian and Henry J. Schiller
Chapter 27 Bacterial and Fungal Infections in Necrotizing Pancreatitis: Pathogenesis, Prevention, and Treatment (pages 288?297): Bettina M. Rau and Hans G. Beger
Chapter 31 Endoscopic Treatment of Necrotizing Pancreatitis (pages 331?335): Stefan Seewald, Salem Omar and Nib Soehendra
Chapter 33 Management of Fluid Collections in Acute Pancreatitis (pages 344?355): Gregory Stringfellow, Eric Vansonnenberg, Giovanna Casola, Gerhard R. Wittich, Sridhar Shankar and Ray Shamos
Chapter 34 Management of Pancreatic Fistula in Acute Pancreatitis (pages 356?361): Jens Werner and Markus W. Buchler
Chapter 35 Enteral Nutrition and Parenteral Nutrition (pages 362?367): Keiko Shiratori
Chapter 36 Long?Term Outcome after Acute Pancreatitis (pages 368?372): Werner Hartwig, Jens Werner and Markus W. Buchler
Chapter 28 Indications for Interventional and Surgical Treatment of Acute Pancreatitis (pages 298?307): Thomas E. Clancy and Stanley W. Ashley
Chapter 29 Surgical Management of Necrotizing Pancreatitis (pages 308?320): Bettina M. Rau, Hans G. Beger, Raymond Aerts, Freddy M. Penninckx, J. Ruben Rodriguez, Carlos Fernandez?del Castillo and Andrew L. Warshaw
Chapter 30 Strategies for Surgical Treatment of Pseudocysts after Acute Pancreatitis (pages 321?330): Antonio Ramos?De la Medina, Kaye M. Reid?Lombardo and Michael G. Sarr
Chapter 32 Minimal?Access Surgical Treatment of Necrotizing Pancreatitis and Pancreatic Abscess (pages 336?343): Saxon Connor, Michael G. T. Raraty, Jonathon Evans and John P. Neoptolemos
Chapter 37 Chronic Pancreatitis: Consequences of Recurrent Acute Episodes (pages 373?382): Gunter Kloppel
Chapter 38 Fibrogenesis of the Pancreas: The Role of Stellate Cells (pages 383?392): Max G. Bachem, Shaoxia Zhou, Wilhelm Schneiderhan and Marco Siech
Chapter 39 Epidemiology and Pathophysiology of Alcoholic Chronic Pancreatitis (pages 393?402): Stephen J. Pandol, Aurelia Lugea, Anna S. Gukovskaya and Ilya Gukovsky
Chapter 40 Hereditary Chronic Pancreatitis (pages 403?411): David C. Whitcomb
Chapter 41 Epidemiology and Pathogenesis of Tropical Chronic Pancreatitis (pages 412?419): Rakesh K. Tandon
Chapter 42 Autoimmune Pancreatitis (pages 420?426): Kazuichi Okazaki
Chapter 43 Cystic Fibrosis?Associated Pancreatitis (pages 427?436): David C. Whitcomb
Chapter 44 Chronic Pancreatitis: A Risk Factor for Cancer? (pages 437?443): Albert B. Lowenfels and Patrick Maisonneuve
Chapter 45 Molecular understanding of Chronic Pancreatitis (pages 444?453): David C. Whitcomb
Chapter 46 Pain Mechanisms in Chronic Pancreatitis (pages 454?457): Fabio F. di Mola and Pierluigi di Sebastiano
Chapter 47 Clinical and Laboratory Diagnosis of Chronic Pancreatitis (pages 458?468): Julia Mayerle, Peter Simon and Markus M. Lerch
Chapter 48 Contrast?Enhanced Computed Tomography and Magnetic Resonance Imaging (pages 469?476): Hans?Jurgen Brambs
Chapter 49 Endoscopic Retrograde Cholangiopancreatography, Magnetic Resonance Cholangiopancreatography, and Endoscopic Ultrasound in Chronic Pancreatitis (pages 477?483): Andrew S. Ross and Irving Waxman
Chapter 50 Natural Course of Chronic Pancreatitis (pages 484?494): Paul Georg Lankisch
Chapter 51 Treatment of Pseudocysts in Chronic Pancreatitis (pages 495?503): Syed A. Ahmad and Jeffrey B. Matthews
Chapter 52 Medical Treatment of Chronic Pancreatitis (pages 504?526): Joachim Mossner, Peter Layer, Jutta Keller, Daniel K. Mullady, Stephen J. D. Oi’Keefe, Nathan Howes, William Greenhalf and Michael G. T. Raraty
Chapter 53 Endoscopic and Interventional Therapy of Chronic Pancreatitis (pages 527?536): Richard A. Kozarek
Chapter 54 Strategies for Surgical Treatment of Chronic Pancreatitis (pages 537?560): Hans G. Beger, Frank Gaunsauge, Michael Schwarz, Bertram Poch, Oscar J. Hines, Howard A. Reber, Bettina M. Rau, Kaye M. Reid?Lombardo, Michael B. Farnell, Michael G. Sarr, Colin J. McKay and Peter Wysocki
Chapter 55 Chronic Pancreatitis: Late Outcome after Medical and Surgical Treatment (pages 561?564): Hans G. Beger and Bertram Poch
Chapter 56 Management of Pancreatic Diabetes Secondary to Chronic Pancreatitis (pages 565?570): Keiko Shiratori
Chapter 57 Epidemiology of Pancreatic Cancer (pages 571?582): Nicholas Alexakis, Paula Ghaneh and John P. Neoptolemos
Chapter 58 Molecular Biological Understanding of Development of Pancreatic Cancer (pages 583?590): Eithne Costello
Chapter 59 Familial Pancreatic Cancer (pages 591?600): William Greenhalf, Louis J. Vitone and John P. Neoptolemos
Chapter 60 Pathology of Exocrine Pancreatic Tumors (pages 601?613): Gunter Kloppel, Bence Sipos and David S. Klimstra
Chapter 61 Precancerous Lesions (pages 614?620): Roland M. Schmid
Chapter 62 Role of Endoscopic Ultrasound for Diagnosis and Differential Diagnosis of Neoplastic Lesions (pages 621?628): Drew Schembre
Chapter 63 Radiologic Diagnosis of Pancreatic Cancer: Computed Tomography and Magnetic Resonance Imaging (pages 629?635): Enrique Lopez Hanninen and Roland Felix
Chapter 64 Screening of Hereditary Pancreatic Cancer Families (pages 636?642): Christopher Carlson, William Greenhalf and Teresa A. Brentnall
Chapter 65 Clinical Assessment and Staging of Pancreatic Cancer (pages 643?647): J. Ruben Rodriguez, Andrew L. Warshaw and Carlos Fernandez?Del Castillo
Chapter 66 Role of Positron Emission Tomography in Diagnosis of Pancreatic Cancer and Cancer Recurrence (pages 648?657): Helmut Friess, Mert Erkan, Jorg Kleeff, Uwe Haberkorn and Markus W. Buchler
Chapter 67 Tumor Markers in Pancreatic Malignancies (pages 658?667): Fuyuhiko Motoi, Shin?Ichi Egawa and Seiki Matsuno
Chapter 68 The Role of Laparoscopy and Peritoneal Cytology in the Management of Pancreatic Cancer (pages 668?677): Kevin Conlon and Paul Balfe
Chapter 69 Pancreatic Cancer Staging Systems and their Clinical Impact (pages 678?681): Hans G. Beger and Dieter Birk
Chapter 70 Endoscopic and Interventional Palliation of Pancreatic Cancer (pages 682?688): Todd H. Baron
Chapter 71 Pancreatic Cancer: Indications for Resection (pages 689?695): Akimasa Nakao
Chapter 72 Pancreaticoduodenectomy for Pancreatic Cancer: Results after Kausch?Whipple and Pylorus?Preserving Resection (pages 696?706): Ramon E. Jimenez and Andrew L. Warshaw
Chapter 73 Extended Radical Surgery for Pancreatic Cancer (pages 707?713): Jens Werner and Markus W. Buchler
Chapter 74 Palliative Pancreaticoduodenectomy: Benefits and Limitations (pages 714?718): Helmut Friess, Jorg Kleeff, Mert Erkan and Markus W. Buchler
Chapter 75 Bypass Surgery for Advanced Pancreatic Cancer (pages 719?726): Jurgen Weitz, Peter Kienle and Markus W. Buchler
Chapter 76 Neoadjuvant Treatment of Pancreatic Cancer: Borderline?Resectable Disease (pages 727?740): Gauri Varadhachary, Christopher H. Crane, Eric P. Tamm, Huamin Wang, Robert A. Wolff and Douglas B. Evans
Chapter 77 Adjuvant Chemotherapy in Pancreatic Cancer (pages 741?748): Paula Ghaneh and John P. Neoptolemos
Chapter 78 Palliative Chemotherapy for Advanced Pancreatic Cancer (pages 749?756): Yu Jo Chua and David Cunningham
Chapter 79 Management of Cancer Pain (pages 757?764): Sergio Pedrazzoli, Claudio Pasquali, Cosimo Sperti and Francesca Avogaro
Chapter 80 Role of Radiotherapy in the Treatment of Pancreatic Cancer (pages 765?771): Shilpen Patel, Michael C. Garofalo and William F. Regine
Chapter 81 Management of Cancer Recurrence (pages 772?775): Helmut Friess, Jorg Kleeff and Markus W. Buchler
Chapter 82 Survival and Late Morbidity after Resection of Pancreatic Cancer (pages 776?784): Osamu Ishikawa, Hiroaki Ohigashi, Hidetoshi Eguchi, Yo Sasaki, Terumasa Yamada and Shingi Imaoka
Chapter 83 Diagnosis of Endocrine Tumors of the Pancreas (pages 785?793): Masayuki Imamura
Chapter 84 Islet Cell Tumors (pages 794?801): Peter E. Goretzki and Hans?Dietrich Roher
Chapter 85 Pancreatic Endocrine Tumors in Multiple Endocrine Neoplasia Syndrome (pages 802?812): Elisabeth Spilcke?Liss, Peter Simon, Markus M. Lerch and Henri Wallaschofski
Chapter 86 Nonfunctioning Endocrine Tumors (pages 813?817): Hodaka Amano, Tadahiro Takada, Fumihiko Miura, Takehide Asano, Masahiro Yoshida, Naoyuki Toyota, Keita Wada, Takahiro Isaka, Naoyuki Tamura and Kenichiro Kato
Chapter 87 Surgical Treatment of Endocrine Tumors (pages 818?822): Masayuki Imamura
Chapter 88 Treatment of Carcinoids of the Pancreas and Biliary Tract (pages 823?831): Andrea Frilling and Vito Cicinnati
Chapter 89 Nonsurgical Management of Endocrine Tumors (pages 832?838): Rudolf Arnold and Anja Rinke
Chapter 90 Liver Transplantation in Advanced Disease of Endocrine Tumors (pages 839?844): Christoph E. Broelsch and Andrea Frilling
Chapter 91 Long?Term Outcome after Treatment of Endocrine Tumors (pages 845?852): Henning Dralle, Andreas Machens, Michael Brauckhoff and Oliver Gimm
Chapter 92 Periampullary Tumors: Clinical Presentation and Diagnostic Strategy (pages 853?862): Amanda B. Cooper and Keith D. Lillemoe
Chapter 93 Histology of Cancer of the Papilla, Distal Common Bile Duct, and Duodenum (pages 863?869): Hans?Peter Fischer
Chapter 94 Adenoma and Adenocarcinoma of the Ampulla of Vater: Diagnosis and Management (pages 870?879): William R. Brugge and Andrew L. Warshaw
Chapter 95 Endoscopic Treatment of Adenomas of the Ampulla of Vater: Benefits and Limits (pages 880?884): Richard A. Kozarek and L. William Traverso
Chapter 96 Surgical Treatment of Periampullary Cancer: Early and Late Results after Resection (pages 885?889): Hans G. Beger, Bertram Poch and Bettina M. Rau
Chapter 97 Histology of Cystic Tumors of the Pancreas (pages 891?911): Wataru Kimura
Chapter 98 Diagnostic Imaging of Cystic Tumors (pages 912?917): Masao Tanaka, Kiichiro Kobayashi, Reiko Tanabe and Koji Yamaguchi
Chapter 99 Diagnosis and Natural History of Intraductal Papillary Mucinous Neoplasms (pages 918?923): L. William Traverso and Richard A. Kozarek
Chapter 100 Mucinous Cystic Neoplasm (pages 924?931): Suresh T. Chari and Thomas C. Smyrk
Chapter 101 Surgical Treatment and Long?Term Outcome of Cystic Neoplasms of the Pancreas (pages 932?939): Carlos Fernandez?Del Castillo and Andrew L. Warshaw
Chapter 102 Minimally Invasive and Local Ablation Techniques of Serous and Mucinous Cystic Lesions (pages 940?946): Laureano Fernandez?Cruz
Chapter 103 Transplantation of Pancreatic Islets (pages 947?959): Reinhard G. Bretzel and Mathias D. Brendel
Chapter 104 Transplantation of the Pancreas (pages 960?969): Markus K. Muller and Hans W. Sollinger